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Safety of RU-486, compared
to other abortion methods:

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Many pro-life groups believe that RU-486 is unsafe:
bullet The National Right to Life Committee state that RU-486 pills "offer a whole new set of significant risks." They are concerned that the pill makes abortion too easy. It gives "supporters of abortion a chance to change the image of abortion, making it seem as simple as taking a pill."
bullet An essay on an unofficial Roman Catholic web site comments: "As far as safety is concerned, complete cardiovascular collapse and death immediately following administration of RU486 has been reported in the European medical literature." 1

The latter is a true statement; it describes the only fatality that occurred to a European woman taking RU486. However, it does not tell the full story. RU-486 is a safe method to terminate a pregnancy, as long as it is not used on women with any of three contraindications -- a history of: 

bullet heavy smoking, 
bullet heart problems, or
bullet high blood pressure. 

After extensive use in Europe, one fatality occurred to a woman who should never have been given the pill, because all three contraindications applied to her. In addition, an older form of prostaglandin was injected in her case. This is no longer used in France and elsewhere. Misoprostol is now used in combination with RU486. One death among 500,000 women using RU-486 was used compares very favorably with the fatality rate if the pregnancies had been allowed continued to term.  Trials have been conducted in 20 countries, including France, Germany, the Netherlands, Scandinavian countries, the former Soviet Union, Spain, Switzerland, the UK, and the U.S. The U.S. trial was concluded on 2,100 women who had been pregnant fewer than 7 weeks.

One source compared the safety of various alternatives in North America:

bullet RU-486: 1 death in 200,000 abortions.
bullet Vacuum aspiration abortion: 1 death in 200,000 abortions
bullet Childbirth 1 death in 14,300 pregnancies
bullet Illegal abortions 1 death in 3,000 abortions. 2,3

After the pills had been available for about four years in the U.S., the Food and Drug Administration reported that three women had died from bacteria infections in the uterus which later spread to their blood supply, leading to sepsis (a.k.a. blood poisoning). By that time, about 360,000 women had  use RU-486. This is a fatality rate of 1 death in 120,000, which makes the use of the medication eight times safer than continuing the pregnancy to childbirth in the U.S.. 4

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Deaths that may have been related to RU-486:

A U.S. Food and Drug Administration report describes the "side effects and complications arising from the use of RU-486 during the time it has been available in the U.S. Market:" from 1997-NOV to 2001-NOV. Unfortunately, the report lumps together men and women who took the drug, ranging in age from teenagers to persons in their 70's. Some women took the drug to end early pregnancies; men and other women took RU-486 to treat medical problems unrelated to abortion. Only 33 persons -- four men and 29 women -- were reported to have experienced adverse side effects. Three men and two women died; RU-486 was listed as the primary suspected cause of death. Dr. Beverly Winikoff, director of reproductive health for the Population Council, said: 

"These are not side effects. This list is a list of things that happened to women who took this drug for any reason, and it's anything that happened to them after they took the drug. But it's not necessarily a drug side effect." 5

One Canadian woman died in the year 2001 after having taking RU-486 to terminate a pregnancy. The cause of death was septic shock as a result of a clostridium bacterial infection. This is a bacterium that is commonly found "in soil and water, and occasionally in the gastrointestinal tract of animals and humans." Christina Horzepa, spokesperson for Population Council said: "We believe the death is unrelated to the drug." She said that clostridium infection is rare and has never been associated with medical abortion in the past. 6

2002-AUG-21: Three U.S. pro-life groups, Concerned Women for America, the Christian Medical Association, and the American Association of Pro-Life Obstetricians and Gynecologists petitioned the Food and Drug Administration to take RU-486 off the market immediately. They say that the pill is jeopardizing women's lives. They seem to have based their conclusions on the Food and Drug Administration report mentioned above; they cited two deaths and four serious side effects among women taking the pill. 7

2003-SEP-17: Holly Patterson, 18, of Livermore, CA, died of complications after taking RU-486 during 2003-SEP. She allegedly experienced bleeding and very severe cramps after taking the pill. She went to the hospital and was only given painkillers. She returned to hospital a few days later and died on SEP-17. Her father speculates that RU-486 induced a partial miscarriage. Fragments of the embryo left inside her uterus became infected and caused her to go into septic shock. A spokesperson for Danco Laboratories, the producer of RU-486 in the U.S. estimated that 200,000 women in the U.S. have used the pill. 8

bullet Assuming that the California teenager died as a result of taking RU-486, then:
bullet The death rate among the 200,000 who had taken RU-486 in the past was 1 in 200,000.
bullet If those 200,000 women had decided to not take RU-486 and had chosen a vacuum aspiration abortion, then 1 in 200,000 would probably have died due to the abortion.
bullet If the 200,000 women had decided to not have an abortion but had continued with their pregnancies, then 14 in 200,000 would have died as a result of their pregnancy.

Thus, we can conclude that:

bullet To pro-choicers, the use of RU-486 prevented the birth of 200,000 unwanted babies and prevented the deaths of 13 women.
bullet To pro-lifers, the use of RU-486 caused the deaths of 200,000 humans: about 1 adult and 200,000 embryos -- which they consider to be human persons.
bullet Forcing women seeking abortions to undergo surgical abortions instead of using RU-486 would have no impact on the death rate from abortions.

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Deaths apparently linked to unapproved procedure:

A group of four or five women who had taken RU486 died after having using a method not approved by the FDA. They died of sepsis, an infection of the bloodstream. The FDA procedure involves swallowing three Mifeprex tablets followed two days later by two misoprostol pills. However, studies had shown that if the misoprostol pills were administered vaginally, they were equally effective and had fewer side effects. This procedure had been recommended by most abortion clinics.

By early 2006, Planned Parenthood estimated that RU-486 had been used 560,000 times in the U.S. since the pill was authorized in the year 2000. The pill had a fatality rate of 1 in about 62,000 uses. This is about a quarter of the fatality rate if the pregnancies had been taken to childbirth. However, five of those women had followed an procedure that is not approved by the FDA. For those women who followed the FDA procedure, the fatality rate was 1 in about 140,000 abortions -- about a tenth of the fatality rate of continuing the pregnancy to childbirth, and roughly equal to the fatality rate of abortions by aspiration.

Some individuals who are opposed to the use of RU-486 are very concerned about the numbers of deaths.

bullet Rep. Chris Smith, (R-NJ) said: "How many deaths, investigations and warnings will it take before RU486 is properly labelled as lethal and removed from the market?"
bullet In the Senate, Jim DeMint (R-SC) and Tom Coburn (R-OK) are promoting a bill to suspend sales of RU-486 until the Government Accountability Office studies the FDA's approval procedure. The bill is informally called "Holly's Law" and is named after Holly Patterson, a teenager, died after taking the pills. DeMint said: "RU-486 is a deadly drug that is killing pregnant women. This drug should never have been approved, and it must be suspended immediately."
bullet Patterson's father said: "The bottom line is that this is not about the abortion debate. This is about the safety, health and welfare of women."

The Associated Press stated that: "The FDA previously has said the abortion pill remains safe enough to stay on the market. The rate of sepsis is about one in 100,000 uses, comparable to infection risks with surgical abortions and childbirth." The FDA issued an alert on MAR-17 recommending that doctors and patients be aware of the possibility of infection following the use of RU-486. Symptoms of infection may include abdominal pain, nausea, vomiting, diarrhea, and weakness, with or without a fever. 9

Planned Parenthood Federation of America, Inc. said it would stop recommending vaginal insertion of misoprostol in favor of swallowing them as approved by the FDA. 10

The Food and Drug Administration, the Centers for Disease Control and Prevention, and the National Institute of Allergy and Infectious Diseases convened a conference, on 2006-MAY-11. Attendees discussed Clostridium sordellii, a bacteria related to the deaths of four California women who had taken RU-486. Inside Bay Area reports:

"While scientists and health officials have confirmed that the women shared the unusual bacterial infection, they are unsure how they contracted it and whether it is related to Mifeprex" or Misoprostol.

Clostridium difficile will also be discussed. It is a different bacteria which has infected patients at hospitals and nursing homes and is unrelated to the abortion pill. 11

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The following information sources were used to prepare and update the above essay. The hyperlinks are not necessarily still active today.

  1. S. Boyd, "Give us liberty: The approval of RU-486 isn't about morals, it's about options," at:
  2. Childbirth by Choice Trust has a very complete and balanced article on U-486 at:
  3. "RU 486: The 'Abortion Pill'," Childbirth by Choice Trust, 2001-JAN, at:
  4. "Feds Strengthen Warnings on Abortion Drug," ConsumerAffairs.Com, 2004-NOV-16, at:
  5. Christine Hall, "FDA Data on RU-486 Spotty, Inconclusive,", at:
  6. Jason Pierce, "Canadian Woman Dies in RU-486 Trial Run," at:
  7. "Washington in Brief: Groups urge abortion pill withdrawn," Washington Post, 2002-AUG-22, at:
  8. "California Teen Dies After Complications from Abortion Pill," Associated Press, 2003-SEP-33, at:
  9. Deaths prompt abortion pill review,"
  10. "Two more women die after taking 'abortion pill'. Unclear whether deaths related to unapproved use of RU-486," Associated Press, 2006-MAR-17, at:
  11. Rebecca Vesely, "State deaths lead to meeting on abortion pill," Inside Bay Area, 2006-APR-07, at:

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Copyright 1997 to 2020 by Ontario Consultants on Religious Tolerance
Latest update: 2006-AUG-04
Author: B.A. Robinson

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